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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1992-12-1
|
| pubmed:abstractText |
Intraperitoneal immunization of mice and subsequent challenge with purified cholera toxin (CT) were employed to evaluate the anti-cholera toxin protective effect of two new oral cholera vaccines, live CVD 103-HgR and killed B subunit-whole cell (BS-WC). CVD 103-HgR vaccine demonstrated 100% protection of mice against 2.25 LD50 and 70% against 3 LD50 of CT. Mice immunized with BS-WC vaccine were protected against 2.25 and 3 LD50 of CT in 88 and 62% of cases, respectively. All three killed parenteral vaccines failed to protect against CT. We suggest this mouse system for preliminary evaluation of the antitoxic protective activity of cholera vaccines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0264-410X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
735-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1441727-Animals,
pubmed-meshheading:1441727-Antitoxins,
pubmed-meshheading:1441727-Cholera,
pubmed-meshheading:1441727-Cholera Toxin,
pubmed-meshheading:1441727-Cholera Vaccines,
pubmed-meshheading:1441727-Drug Evaluation, Preclinical,
pubmed-meshheading:1441727-Immunization,
pubmed-meshheading:1441727-Injections, Intraperitoneal,
pubmed-meshheading:1441727-Lethal Dose 50,
pubmed-meshheading:1441727-Male,
pubmed-meshheading:1441727-Mice
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Experimental evaluation of antitoxic protective effect of new cholera vaccines in mice.
|
| pubmed:affiliation |
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892.
|
| pubmed:publicationType |
Journal Article
|