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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-12-23
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pubmed:abstractText |
To determine whether the decline in pulmonary function in smokers is modified by stop-smoking intervention, a randomized controlled study (the Multiple Risk Factor Intervention Trial) was done comparing participants in a special intervention group that included an intensive smoking cessation program with those assigned to usual care. The subjects were 6,347 middle-aged male smokers who had serial measurements of pulmonary function--principally the forced expiratory volume in 1 second (FEV1)--during 6 to 7 years of follow-up. No overall differences were detected in the rate of loss of FEV1 in the two groups. The use of beta-blockers, which had detrimental effects on FEV1, was significantly more common in the intervention group. Among nonusers of beta-blockers, heavy smokers lost FEV1 at a rate about 11 ml per year slower in the intervention group than in the control group (2P = .09) and ended the trial with an FEV1 about 90 ml higher (2P = .05). These results support the inference from observational studies that smoking cessation has a beneficial effect on pulmonary function in heavy smokers.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-1094879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-1441512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-1758842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-3102916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-3202458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-3565927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-3573245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-370171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-3802843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-4866848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-49736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-5922891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-6497153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-6978096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-7027239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-7111675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-7224350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-7235353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-869087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-937827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-937828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1441495-970747
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0093-0415
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
534-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
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pubmed:year |
1992
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pubmed:articleTitle |
Effects of the multiple risk factor intervention trial smoking cessation program on pulmonary function. A randomized controlled trial.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, University of California, School of Medicine, San Francisco.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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