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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
1
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pubmed:dateCreated |
1992-12-4
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pubmed:abstractText |
Content of tocopherol and total antiradical activity of hydrophobic antioxidants were estimated in human blood platelets. Two hydrophobic antioxidants--tocopherol and ubiquinone were detected in hexane extracts of thrombocytes using thin-layer chromatography. After incubation of thrombocytes with N-ethyl maleimide content of malonyl dialdehyde was increased and of tocopherol--decreased, receptor-dependent increase of Ca2+ concentration in cytoplasm was potentiated, while the Ca(2+)-blocking effect of nitroglycerol was decreased. Nitroglycerol did not inhibit the N-ethyl maleimide effect on content of malonyl dialdehyde in blood platelets. Addition of exogenous vitamin E to thrombocytes did not affect the receptor-dependent increase of Ca2+ concentration. Ascorbic acid inhibited the receptor-dependent increase of Ca2+ concentration. The data obtained suggest that nitrates may be used more rationally in combination with antioxidants and/or inhibitors of cyclooxygenase.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0042-8809
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1441291-Antioxidants,
pubmed-meshheading:1441291-Ascorbic Acid,
pubmed-meshheading:1441291-Blood Platelets,
pubmed-meshheading:1441291-Calcium,
pubmed-meshheading:1441291-Cell Membrane,
pubmed-meshheading:1441291-Chromatography, Thin Layer,
pubmed-meshheading:1441291-Ethylmaleimide,
pubmed-meshheading:1441291-Humans,
pubmed-meshheading:1441291-Lipid Peroxidation,
pubmed-meshheading:1441291-Malondialdehyde,
pubmed-meshheading:1441291-Nitroglycerin,
pubmed-meshheading:1441291-Ubiquinone,
pubmed-meshheading:1441291-Vitamin E
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pubmed:articleTitle |
[Antioxidants, lipid peroxidation, and receptor-dependent increase in Ca2+ concentration in human platelets].
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pubmed:publicationType |
Journal Article,
English Abstract
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