Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-12-11
|
| pubmed:abstractText |
Lazaroids are a class of novel 21 aminosteroids. They have been reported to be potent inhibitors of lipid peroxidation, which is a major contributing factor to ischemia-reperfusion injury in the lung. A Lewis rat orthotopic left lung isotransplant model was used to investigate the effects of the lazaroid U74500A on pulmonary preservation. The heart-lung blocks of donor rats were flushed with and then stored in either standard University of Wisconsin solution or University of Wisconsin solution with 30 mumol/L of U74500A substituted for the dexamethasone. After 6 or 12 hours of cold storage at 0 degrees C, the left lungs were transplanted into recipient rats and reperfused for 1 hour. Pulmonary function was assessed by measuring oxygen and carbon dioxide tensions in arterial blood after removal of the right lung. Lipid peroxide concentrations were measured as a thiobarbituric acid-reactive substance. Although arterial oxygen and carbon dioxide pressures and water content after 6 hours of preservation followed by reperfusion were similar in both the lazaroid and dexamethasone groups, lipid peroxide concentration was significantly higher in the dexamethasone group (0.88 +/- 0.07 mumol/gm) than in the lazaroid group (0.54 +/- 0.07 mumol/gm) (p < 0.01). After 12 hours of preservation, there were significant differences between the lazaroid and dexamethasone groups in arterial oxygen pressure (339 +/- 70 vs 27 +/- 3 mm Hg, p < 0.01), arterial carbon dioxide pressure (24.3 +/- 2.7 vs 47.7 +/- 7.0 mm Hg, p < 0.001), and lipid peroxide concentrations (0.69 +/- 0.07 vs 1.30 +/- 0.09 mumol/gm, p < 0.001). We conclude that addition of U74500A to the flush and storage solution enhances the preservation of the pulmonary graft in this transplant model.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Allopurinol,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Dioxide,
http://linkedlifedata.com/resource/pubmed/chemical/Cardioplegic Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Organ Preservation Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnatrienes,
http://linkedlifedata.com/resource/pubmed/chemical/Raffinose,
http://linkedlifedata.com/resource/pubmed/chemical/Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/U 74500A,
http://linkedlifedata.com/resource/pubmed/chemical/University of...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-5223
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1333-9
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1434715-Adenosine,
pubmed-meshheading:1434715-Allopurinol,
pubmed-meshheading:1434715-Animals,
pubmed-meshheading:1434715-Body Water,
pubmed-meshheading:1434715-Carbon Dioxide,
pubmed-meshheading:1434715-Cardioplegic Solutions,
pubmed-meshheading:1434715-Cold Temperature,
pubmed-meshheading:1434715-Dexamethasone,
pubmed-meshheading:1434715-Glutathione,
pubmed-meshheading:1434715-Insulin,
pubmed-meshheading:1434715-Ischemia,
pubmed-meshheading:1434715-Lipid Peroxides,
pubmed-meshheading:1434715-Lung,
pubmed-meshheading:1434715-Male,
pubmed-meshheading:1434715-Organ Preservation,
pubmed-meshheading:1434715-Organ Preservation Solutions,
pubmed-meshheading:1434715-Oxygen,
pubmed-meshheading:1434715-Pregnatrienes,
pubmed-meshheading:1434715-Raffinose,
pubmed-meshheading:1434715-Rats,
pubmed-meshheading:1434715-Rats, Inbred Lew,
pubmed-meshheading:1434715-Reperfusion Injury,
pubmed-meshheading:1434715-Solutions
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Lazaroid U74500A as an additive to University of Wisconsin solution for pulmonary grafts in the rat transplant model.
|
| pubmed:affiliation |
Division of Cardiothoracic Surgery, University of Pittsburgh, Pa.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|