Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1965-12-1
pubmed:abstractText
1. Liver mitochondria suspended in an iso-osmotic buffered potassium chloride medium containing an oxidizable substrate and phosphate accumulated added Ca(2+). During this process H(+) appeared in the medium and the mitochondrial suspension showed increased light-scattering. Respiration was markedly stimulated. 2. The addition of excess of Ca(2+), respiratory inhibitors or uncoupling agents caused extensive mitochondrial swelling associated with release of Ca(2+) into the suspending medium. When the suspension became anaerobic extensive swelling also occurred. Only under conditions when the addition of uncoupling agents would have produced high rates of electron transport, e.g. in the presence of succinate, was the structural integrity of the mitochondrion maintained after Ca(2+) accumulation. 3. Conditions that prevented respiration-dependent Ca(2+) accumulation also prevented Ca(2+)-induced swelling. Bovine plasma albumin was without effect, indicating that U-factor was not involved. Oligomycin together with ADP or ATP partially stabilized the mitochondria against Ca(2+)-induced swelling. 4. It is suggested that a ;high-energy' intermediate generated by coupled electron transport is required to prevent the mitochondrial swelling that results as a consequence of Ca(2+) accumulation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13032109, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13095885, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13252035, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13344467, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13367006, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13403919, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13666800, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13692427, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13762256, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13809258, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13890775, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13907155, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-13929376, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14007889, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14015424, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14020173, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14085406, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14340089, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14340090, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14415393, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-14429695, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-4378636, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-5832294, http://linkedlifedata.com/resource/pubmed/commentcorrection/14340088-5890939
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/ADENOSINE TRIPHOSPHATE, http://linkedlifedata.com/resource/pubmed/keyword/ARSENICALS, http://linkedlifedata.com/resource/pubmed/keyword/CALCIUM METABOLISM, http://linkedlifedata.com/resource/pubmed/keyword/CHELATING AGENTS, http://linkedlifedata.com/resource/pubmed/keyword/ELECTRON TRANSPORT, http://linkedlifedata.com/resource/pubmed/keyword/EXPERIMENTAL LAB STUDY, http://linkedlifedata.com/resource/pubmed/keyword/LIVER CYTOLOGY, http://linkedlifedata.com/resource/pubmed/keyword/METABOLISM, http://linkedlifedata.com/resource/pubmed/keyword/MITOCHONDRIA, http://linkedlifedata.com/resource/pubmed/keyword/OLIGOMYCIN, http://linkedlifedata.com/resource/pubmed/keyword/OXIDATIVE PHOSPHORYLATION, http://linkedlifedata.com/resource/pubmed/keyword/PHARMACOLOGY, http://linkedlifedata.com/resource/pubmed/keyword/PHOSPHATES, http://linkedlifedata.com/resource/pubmed/keyword/RATS
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
378-86
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1965
pubmed:articleTitle
CALCIUM ION ACCUMULATION AND VOLUME CHANGES OF ISOLATED LIVER MITOCHONDRIA. CALCIUM ION-INDUCED SWELLING.
pubmed:publicationType
Journal Article