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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1992-12-1
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pubmed:abstractText |
To understand the biologic processes involved in transmission of HIV, we examined the genital tracts of chronically infected female macaques and localized SIV-infected cells. SIV was found in the genital tract of 12 of 16 animals and SIV-infected cells were located in the cervix and vagina. Inoculation of cell-free SIV into the blind vaginal pouch of hysterectomized macaques resulted in systemic infection. We propose a hypothesis to explain the early events in the genital transmission of SIV.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0047-2565
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
64-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1433268-Animals,
pubmed-meshheading:1433268-Cervix Uteri,
pubmed-meshheading:1433268-Disease Models, Animal,
pubmed-meshheading:1433268-Female,
pubmed-meshheading:1433268-Genitalia, Female,
pubmed-meshheading:1433268-Immunohistochemistry,
pubmed-meshheading:1433268-Macaca mulatta,
pubmed-meshheading:1433268-Nucleic Acid Hybridization,
pubmed-meshheading:1433268-RNA, Viral,
pubmed-meshheading:1433268-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1433268-Simian immunodeficiency virus,
pubmed-meshheading:1433268-Vagina,
pubmed-meshheading:1433268-Viremia
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pubmed:articleTitle |
Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques.
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pubmed:affiliation |
California Regional Primate Research Center, University of California, Davis 95616.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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