| pubmed-article:1431316 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1431316 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:1431316 | lifeskim:mentions | umls-concept:C0600531 | lld:lifeskim |
| pubmed-article:1431316 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:1431316 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:1431316 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:1431316 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:1431316 | lifeskim:mentions | umls-concept:C1521805 | lld:lifeskim |
| pubmed-article:1431316 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1431316 | pubmed:dateCreated | 1992-12-22 | lld:pubmed |
| pubmed-article:1431316 | pubmed:abstractText | Three variants of the human monoblastic cell line U937 with different degrees of sensitivity to the antiproliferative action of interferon-alpha (IFN-alpha were examined for phenotypic differences. The highly IFN-sensitive variant U937-V expressed twice as many IFN-alpha binding sites as both its IFN-alpha-resistant derivative U937-VR and the cell line U937 exhibiting a 20-fold reduction in IFN-alpha sensitivity as compared to U937-V cells. All three variants were IFN-reactive with regard to induction of 2',5'-oligoadenylate (2-5A) synthetase activity and were similarly sensitive to the growth-inhibiting action of IFN-gamma and tumor necrosis factor. Responsiveness to the antiproliferative effect of granulocyte-macrophage colony-stimulating factor (GM-CSF), however, was confined to cell lines U937 and U937-VR. Although expressing a comparable number of GM-CSF receptors, the highly IFN-sensitive variant U937-V was refractory to GM-CSF. Flow cytometry revealed a marked difference in the expression of the antigen CD11b which was detectable on 85% of cells of the U937-V line but only on approximately 25% of cells derived from the U937 and U937-VR lines. Results thus demonstrate opposite sensitivity of U937 cells to the growth-inhibiting action of IFN-alpha and GM-CSF, apparently dependent on the state of U937 differentiation as determined by expression of the CD11b antigen. | lld:pubmed |
| pubmed-article:1431316 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1431316 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431316 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1431316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431316 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1431316 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1431316 | pubmed:issn | 0197-8357 | lld:pubmed |
| pubmed-article:1431316 | pubmed:author | pubmed-author:RosePP | lld:pubmed |
| pubmed-article:1431316 | pubmed:author | pubmed-author:MoritaMM | lld:pubmed |
| pubmed-article:1431316 | pubmed:author | pubmed-author:SeeberSS | lld:pubmed |
| pubmed-article:1431316 | pubmed:author | pubmed-author:LEVYJ PJP | lld:pubmed |
| pubmed-article:1431316 | pubmed:author | pubmed-author:NiederleNN | lld:pubmed |
| pubmed-article:1431316 | pubmed:author | pubmed-author:KummerGG | lld:pubmed |
| pubmed-article:1431316 | pubmed:author | pubmed-author:KlokeOO | lld:pubmed |
| pubmed-article:1431316 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1431316 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:1431316 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1431316 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1431316 | pubmed:pagination | 369-76 | lld:pubmed |
| pubmed-article:1431316 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1431316 | pubmed:meshHeading | pubmed-meshheading:1431316-... | lld:pubmed |
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| pubmed-article:1431316 | pubmed:meshHeading | pubmed-meshheading:1431316-... | lld:pubmed |
| pubmed-article:1431316 | pubmed:meshHeading | pubmed-meshheading:1431316-... | lld:pubmed |
| pubmed-article:1431316 | pubmed:meshHeading | pubmed-meshheading:1431316-... | lld:pubmed |
| pubmed-article:1431316 | pubmed:meshHeading | pubmed-meshheading:1431316-... | lld:pubmed |
| pubmed-article:1431316 | pubmed:meshHeading | pubmed-meshheading:1431316-... | lld:pubmed |
| pubmed-article:1431316 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1431316 | pubmed:articleTitle | Opposite sensitivity to the antiproliferative action of interferon-alpha and granulocyte-macrophage colony-stimulating factor in monoblastic U937 cells. | lld:pubmed |
| pubmed-article:1431316 | pubmed:affiliation | Department of Internal Medicine (Cancer Research), West German Cancer Center, University of Essen Medical School. | lld:pubmed |
| pubmed-article:1431316 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1431316 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
