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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-12-22
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pubmed:abstractText |
Local production of growth factors may play a major role in vascular repair after injury. We examined the regulation of insulin-like growth factor-I (IGF-I) and its specific membrane receptor in balloon-denuded rat aorta. Aortic IGF-I mRNA and radioimmunoassayable IGF-I content increased severalfold after balloon denudation with a peak at 7 d after injury. This coincided with a reciprocal 25% decrease in IGF-I receptor mRNA content and a 40% decrease in total 125I-IGF-I binding. Scatchard analysis indicated a single class of binding sites, with a decrease in receptor number at 7 d compared to control and no change in affinity. By in situ hybridization the predominant site of IGF-I expression in the normal and the denuded vessel wall was the medial smooth muscle cell. After denudation there was a relative decrease in IGF-I receptor mRNA in the medial cells as compared to the neointima, suggesting that the site of IGF-I action was predominantly in the medial layer. These data suggest that local expression and action of IGF-I are significant in the promotion of smooth muscle cell proliferation after arterial injury.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-1596294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-1694588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-1825089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-1984855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-205798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2172262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2188750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2477843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2542108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2547834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2683075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2788174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2813399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2843568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-2972706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-3013421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-3453891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-3511384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-3512908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-3554899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-3652657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-3690631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-4008644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-6876748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1430215-6998997
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1926-31
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1430215-Animals,
pubmed-meshheading:1430215-Aorta,
pubmed-meshheading:1430215-Balloon Dilation,
pubmed-meshheading:1430215-Cell Division,
pubmed-meshheading:1430215-Gene Expression Regulation,
pubmed-meshheading:1430215-Insulin-Like Growth Factor I,
pubmed-meshheading:1430215-Male,
pubmed-meshheading:1430215-Muscle, Smooth, Vascular,
pubmed-meshheading:1430215-RNA, Messenger,
pubmed-meshheading:1430215-Rats,
pubmed-meshheading:1430215-Rats, Sprague-Dawley,
pubmed-meshheading:1430215-Receptor, IGF Type 1
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pubmed:year |
1992
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pubmed:articleTitle |
Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity.
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pubmed:affiliation |
Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California 90048-1896.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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