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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1992-12-3
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pubmed:abstractText |
An acrylamide derivative of a thrombin inhibitor was synthesized and graft polymerized to the surfaces of polymer membranes. The thrombin-inhibitor activity was unaffected by the introduction of an acryloyl group. The surface-graft membrane deactivated thrombin markedly and suppressed adhesion of platelets, resulting in a high nonthrombogenicity. Immersion of polymer membranes blended with the thrombin inhibitor in phosphate-buffered saline for 10 d resulted in the loss of nonthrombogenicity, while the polymer membranes grafted with the thrombin inhibitor derivative maintained the nonthrombogenicity over a long period.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9304
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1065-80
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pubmed:dateRevised |
2006-4-17
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pubmed:meshHeading |
pubmed-meshheading:1429756-Acrylamides,
pubmed-meshheading:1429756-Amino Acid Sequence,
pubmed-meshheading:1429756-Animals,
pubmed-meshheading:1429756-Antithrombins,
pubmed-meshheading:1429756-Blood Coagulation,
pubmed-meshheading:1429756-Blood Coagulation Tests,
pubmed-meshheading:1429756-Blood Grouping and Crossmatching,
pubmed-meshheading:1429756-Dogs,
pubmed-meshheading:1429756-Fibrin,
pubmed-meshheading:1429756-Membranes, Artificial,
pubmed-meshheading:1429756-Molecular Sequence Data,
pubmed-meshheading:1429756-Molecular Structure,
pubmed-meshheading:1429756-Pipecolic Acids,
pubmed-meshheading:1429756-Platelet Adhesiveness,
pubmed-meshheading:1429756-Platelet Aggregation,
pubmed-meshheading:1429756-Polymers,
pubmed-meshheading:1429756-Solutions,
pubmed-meshheading:1429756-Surface Properties
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pubmed:year |
1992
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pubmed:articleTitle |
Synthesis and nonthrombogenicity of polymer membrane with surface-graft polymers carrying thrombin inhibitor.
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pubmed:affiliation |
Department of Polymer Chemistry, Kyoto University Yoshida Honmachi, Japan.
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pubmed:publicationType |
Journal Article
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