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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-12-1
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pubmed:abstractText |
The product of a neural retina-specific gene, NRL, belongs to the "leucine zipper" family of DNA-binding proteins and has a strong similarity to the v-maf oncogene product. The NRL gene maps to human chromosome 14 by Southern blot analysis of genomic DNA from a human-rodent somatic cell hybrid panel. In situ hybridization to metaphase chromosomes has further sublocalized the gene to the region 14q11.1-q11.2. D14S46E has now been assigned to the NRL gene. Because of its specific pattern of expression, NRL is a candidate gene for retinal diseases.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0888-7543
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:geneSymbol |
NRL
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-2
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1427865-Animals,
pubmed-meshheading:1427865-Blotting, Southern,
pubmed-meshheading:1427865-Chromosome Mapping,
pubmed-meshheading:1427865-Chromosomes, Human, Pair 14,
pubmed-meshheading:1427865-Cricetinae,
pubmed-meshheading:1427865-DNA-Binding Proteins,
pubmed-meshheading:1427865-Humans,
pubmed-meshheading:1427865-Hybrid Cells,
pubmed-meshheading:1427865-Leucine Zippers,
pubmed-meshheading:1427865-Metaphase,
pubmed-meshheading:1427865-Mice,
pubmed-meshheading:1427865-Neurons,
pubmed-meshheading:1427865-Retina
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pubmed:year |
1992
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pubmed:articleTitle |
Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2.
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pubmed:affiliation |
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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