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Hydroxylamine can induce any one of the four types of transition mutations in bacteriophage S13 if the mutagen is added directly to agar plates seeded with phage and bacterial indicators. The phage can also be mutated by treating the host cell with hydroxylamine before infecting it with phage. These effects of hydroxylamine in vivo contrast with the mutagenic effect in vitro, which seems to be exclusively on cytosine.
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