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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1992-12-18
|
| pubmed:abstractText |
Ten children (6 boys and 4 girls, aged 1-9 years old) underwent operations with a cardiopulmonary bypass, and the technetium-99m hexamethylpropylene amine oxine (99mTc-HMPAO) labelled white blood cell (WBC) heart scans were used to detect postoperative leukocyte infiltration in the hearts. The results showed that 80% (8/10) of the cases had subclinical inflammation in the hearts (grading of WBC scans > or = score 2), and a positive correlation (R = 0.77) was noted between the severity of the inflammation (grading of the WBC scans) and the duration of the cardiopulmonary bypass in the operations. Another control group (9 boys and 2 girls, aged 2-13 years old) underwent operations without a cardiopulmonary bypass, and subclinical inflammation of hearts was demonstrated in only 1 case (9%) by the 99mTc-HMPAO labelled WBC scans (grading of WBC scans < score 2) after the operations. There was a significant difference (P < 0.001, by a Wilcoxon rank sum test) based upon the severity of the ischaemic heart damage in the two groups. In our preliminary conclusions, the 99mTc-HMPAO labelled WBC heart scans may provide non-invasive and directly discernible evidence of subclinical inflammation in the heart due to a transient ischaemic state during a cardiopulmonary bypass, even if the clinical symptoms and signs of carditis are not apparent.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0340-6997
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
960-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1425783-Cardiopulmonary Bypass,
pubmed-meshheading:1425783-Child,
pubmed-meshheading:1425783-Female,
pubmed-meshheading:1425783-Heart,
pubmed-meshheading:1425783-Heart Defects, Congenital,
pubmed-meshheading:1425783-Humans,
pubmed-meshheading:1425783-Leukocytes,
pubmed-meshheading:1425783-Male,
pubmed-meshheading:1425783-Myocardial Reperfusion Injury,
pubmed-meshheading:1425783-Myocarditis,
pubmed-meshheading:1425783-Organotechnetium Compounds,
pubmed-meshheading:1425783-Oximes,
pubmed-meshheading:1425783-Technetium Tc 99m Exametazime
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
The use of technetium-99m hexamethylpropylene amine oxime labelled white blood cells to detect subclinical inflammation of the heart after cardiopulmonary bypass in children with congenital heart disease.
|
| pubmed:affiliation |
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
|
| pubmed:publicationType |
Journal Article
|