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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-12-3
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pubmed:abstractText |
The pharmacokinetics of roxithromycin (300 mg orally) and the influence of the antacid aluminum magnesium hydroxide and the H2-blocker ranitidine on bioavailability of roxithromycin in ten healthy volunteers were studied. Pharmacokinetics after a single dose of roxithromycin were characterized by high peak serum levels (9.1 +/- 2.1 mg/l) and a long elimination half-life (7.2 +/- 2.5 h), resulting in a large area under the curve (116.9 +/- 32.7 mg h/l). High inter- and intraindividual variations were found for both the absorption time and the elimination half-life. The bioavailability of roxithromycin was not affected by coadministration with antacids or ranitidine.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0934-9723
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
465-8
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pubmed:dateRevised |
2009-11-2
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pubmed:meshHeading |
pubmed-meshheading:1425718-Adult,
pubmed-meshheading:1425718-Aluminum Hydroxide,
pubmed-meshheading:1425718-Antacids,
pubmed-meshheading:1425718-Biological Availability,
pubmed-meshheading:1425718-Drug Combinations,
pubmed-meshheading:1425718-Female,
pubmed-meshheading:1425718-Humans,
pubmed-meshheading:1425718-Intestinal Absorption,
pubmed-meshheading:1425718-Magnesium Hydroxide,
pubmed-meshheading:1425718-Male,
pubmed-meshheading:1425718-Ranitidine,
pubmed-meshheading:1425718-Roxithromycin
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pubmed:year |
1992
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|
pubmed:articleTitle |
Pharmacokinetics of roxithromycin and influence of H2-blockers and antacids on gastrointestinal absorption.
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pubmed:affiliation |
Medical Department, Universitätsklinikum Steglitz, Freie Universität Berlin, Germany.
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pubmed:publicationType |
Journal Article
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