| pubmed-article:1425588 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1425588 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1425588 | lifeskim:mentions | umls-concept:C0017345 | lld:lifeskim |
| pubmed-article:1425588 | lifeskim:mentions | umls-concept:C1514829 | lld:lifeskim |
| pubmed-article:1425588 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:1425588 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1425588 | pubmed:dateCreated | 1992-12-18 | lld:pubmed |
| pubmed-article:1425588 | pubmed:abstractText | A viral double-stranded RNA associated with virulence attenuation (hypovirulence) in the chestnut blight fungus (Cryphonectria parasitica) has been shown by DNA-mediated transformation to be responsible for transmissible hypovirulence. In addition to reduced virulence, the fungal strain harboring this virus exhibits a diverse array of characteristics, termed hypovirulence-associated traits, which distinguish it from an isogenic virus-free strain. We have investigated one of these traits, suppressed lac-1 (laccase) transcript accumulation. Two different and opposing regulatory pathways appear to govern lac-1 transcript levels in the virus-free strain: a stimulatory pathway was found to be dependent on the inositol trisphosphate (IP3) and calcium second messenger systems. A second pathway limiting transcript accumulation was shown to require ongoing protein synthesis. Additionally, changes in the level of lac-1 transcript accumulation were found to be related to modulation of promoter activity and this activity was shown to be suppressed in the virus-containing strain. We conclude that this hypovirulence-associated virus interferes with transduction of an IP3-calcium-dependent signal that is required for stimulation of lac-1 transcription. The perturbation of such signal transduction pathways by hypovirulence-associated viruses may account for the manifold symptoms associated with transmissible hypovirulence. | lld:pubmed |
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| pubmed-article:1425588 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1425588 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1425588 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1425588 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1425588 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1425588 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:1425588 | pubmed:author | pubmed-author:NussD LDL | lld:pubmed |
| pubmed-article:1425588 | pubmed:author | pubmed-author:LarsonT GTG | lld:pubmed |
| pubmed-article:1425588 | pubmed:author | pubmed-author:EnkeSS | lld:pubmed |
| pubmed-article:1425588 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1425588 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1425588 | pubmed:geneSymbol | lac-1 | lld:pubmed |
| pubmed-article:1425588 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1425588 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1425588 | pubmed:pagination | 4539-48 | lld:pubmed |
| pubmed-article:1425588 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1425588 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1425588 | pubmed:articleTitle | Regulatory pathways governing modulation of fungal gene expression by a virulence-attenuating mycovirus. | lld:pubmed |
| pubmed-article:1425588 | pubmed:affiliation | Department of Molecular Oncology and Virology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110. | lld:pubmed |
| pubmed-article:1425588 | pubmed:publicationType | Journal Article | lld:pubmed |
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