|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1992-12-18
|
|
pubmed:abstractText |
A viral double-stranded RNA associated with virulence attenuation (hypovirulence) in the chestnut blight fungus (Cryphonectria parasitica) has been shown by DNA-mediated transformation to be responsible for transmissible hypovirulence. In addition to reduced virulence, the fungal strain harboring this virus exhibits a diverse array of characteristics, termed hypovirulence-associated traits, which distinguish it from an isogenic virus-free strain. We have investigated one of these traits, suppressed lac-1 (laccase) transcript accumulation. Two different and opposing regulatory pathways appear to govern lac-1 transcript levels in the virus-free strain: a stimulatory pathway was found to be dependent on the inositol trisphosphate (IP3) and calcium second messenger systems. A second pathway limiting transcript accumulation was shown to require ongoing protein synthesis. Additionally, changes in the level of lac-1 transcript accumulation were found to be related to modulation of promoter activity and this activity was shown to be suppressed in the virus-containing strain. We conclude that this hypovirulence-associated virus interferes with transduction of an IP3-calcium-dependent signal that is required for stimulation of lac-1 transcription. The perturbation of such signal transduction pathways by hypovirulence-associated viruses may account for the manifold symptoms associated with transmissible hypovirulence.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1496400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1535523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1537330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1628615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1655771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1688572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1702384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1715516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1744058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-17771259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1833078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1833465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-1997316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2000146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2446118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2447099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2455767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2527035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2549693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2595372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2992357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2992800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-2994073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-3031065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-3059353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-3135328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-3140380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-3304132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-3322945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-4278535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-4376002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-489672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-4987311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-5415255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-6217413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-6275838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-6341366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-6770893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-7150264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1425588-942051
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0261-4189
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:geneSymbol |
lac-1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4539-48
|
|
pubmed:dateRevised |
2010-9-7
|
|
pubmed:meshHeading |
pubmed-meshheading:1425588-Ascomycota,
pubmed-meshheading:1425588-Base Sequence,
pubmed-meshheading:1425588-Calcium,
pubmed-meshheading:1425588-Cycloheximide,
pubmed-meshheading:1425588-Cyclosporine,
pubmed-meshheading:1425588-DNA, Single-Stranded,
pubmed-meshheading:1425588-Electrophoresis, Agar Gel,
pubmed-meshheading:1425588-Gene Expression Regulation, Fungal,
pubmed-meshheading:1425588-Gene Expression Regulation, Viral,
pubmed-meshheading:1425588-Inositol Phosphates,
pubmed-meshheading:1425588-Laccase,
pubmed-meshheading:1425588-Lithium,
pubmed-meshheading:1425588-Molecular Sequence Data,
pubmed-meshheading:1425588-Oxidoreductases,
pubmed-meshheading:1425588-Promoter Regions, Genetic,
pubmed-meshheading:1425588-RNA Viruses,
pubmed-meshheading:1425588-Transcription, Genetic,
pubmed-meshheading:1425588-Virulence
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Regulatory pathways governing modulation of fungal gene expression by a virulence-attenuating mycovirus.
|
|
pubmed:affiliation |
Department of Molecular Oncology and Virology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.
|
|
pubmed:publicationType |
Journal Article
|
