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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1992-12-14
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pubmed:abstractText |
Nitric oxide synthesis occurs both in vitro and in vivo in response to inflammatory stimuli and can have profound effects on the local cellular environment. Hepatocytes, Kupffer cells, and endothelial cells produce nitric oxide in vitro, but the in vivo role of this reactive mediator in the liver is unknown. We assessed the role of nitric oxide synthesis during endotoxemia in mice by inhibiting its synthesis with NG-monomethyl-L-arginine after lipopolysaccharide injection and by determining the effects of this inhibition on hepatic damage.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0090-3493
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1568-74
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1424701-Acute Disease,
pubmed-meshheading:1424701-Animals,
pubmed-meshheading:1424701-Arginine,
pubmed-meshheading:1424701-Bacteremia,
pubmed-meshheading:1424701-Disease Models, Animal,
pubmed-meshheading:1424701-Dose-Response Relationship, Drug,
pubmed-meshheading:1424701-Drug Evaluation, Preclinical,
pubmed-meshheading:1424701-Female,
pubmed-meshheading:1424701-Inflammation,
pubmed-meshheading:1424701-Lipopolysaccharides,
pubmed-meshheading:1424701-Liver Diseases,
pubmed-meshheading:1424701-Liver Function Tests,
pubmed-meshheading:1424701-Mice,
pubmed-meshheading:1424701-Mice, Inbred BALB C,
pubmed-meshheading:1424701-Nitric Oxide,
pubmed-meshheading:1424701-omega-N-Methylarginine
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pubmed:year |
1992
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pubmed:articleTitle |
Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia.
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pubmed:affiliation |
Department of Surgery, University of Pittsburgh, PA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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