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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0018134,
umls-concept:C0024141,
umls-concept:C0085358,
umls-concept:C0205263,
umls-concept:C0205359,
umls-concept:C0301625,
umls-concept:C0591833,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
1992-12-10
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pubmed:abstractText |
Splenic CD8+ (Lyt-2+) cells of C57BL/6 mice were injected into semiallogeneic (NZB x BXSB)F1 mice, which spontaneously develop lupus nephritis, in order to examine whether the disease was somehow modified by the occurrence of graft-versus-host reaction. The development of lupus nephritis in the F1 recipients was strongly inhibited and immunopathological parameters such as anti-DNA antibodies, circulating immune complexes (CIC) and splenic immunoglobulin-producing cells (IgPC) were markedly reduced. The injection of CD4+ (L3T4+) T cells into F1 recipients did not result in similar effects. These findings suggest that the development of autoimmune disease could be ameliorated by CD8+ cells responding to MHC class I antigens. The significance of the data is discussed in terms of the treatment of autoimmune diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-109524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-1617113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-2397613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-2933483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-3076417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-309911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-3104594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-3409553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-6165672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-6183348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-6218218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-6224882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-6607792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1424284-789096
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
260-5
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1424284-Animals,
pubmed-meshheading:1424284-Antibodies, Antinuclear,
pubmed-meshheading:1424284-Antibody-Producing Cells,
pubmed-meshheading:1424284-Antigen-Antibody Complex,
pubmed-meshheading:1424284-Antigens, CD8,
pubmed-meshheading:1424284-Autoantibodies,
pubmed-meshheading:1424284-Complement C1q,
pubmed-meshheading:1424284-Fluorescent Antibody Technique,
pubmed-meshheading:1424284-Graft vs Host Reaction,
pubmed-meshheading:1424284-Immunoglobulin G,
pubmed-meshheading:1424284-Immunoglobulin M,
pubmed-meshheading:1424284-Lupus Erythematosus, Systemic,
pubmed-meshheading:1424284-Lupus Nephritis,
pubmed-meshheading:1424284-Mice,
pubmed-meshheading:1424284-Spleen,
pubmed-meshheading:1424284-T-Lymphocytes, Regulatory
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pubmed:year |
1992
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pubmed:articleTitle |
Suppression of spontaneous murine lupus by inducing graft-versus-host reaction with CD8+ cells.
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pubmed:affiliation |
Department of Medicine (II), Niigata University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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