| pubmed-article:1424281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0020852 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0282056 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0178587 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1424281 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1424281 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1424281 | pubmed:dateCreated | 1992-12-10 | lld:pubmed |
| pubmed-article:1424281 | pubmed:abstractText | An HLA-DR restricted T cell clone (26G11) which recognized a lymphoid cell-derived autoantigen associated with DR4 molecule was shown to induce not only autologous but also allogenic DR4+ B cells to produce large amounts of antibodies of the IgG and IgM classes. Using the helper activity of this clone, we investigated the mechanism of anti-DNA antibody production in DR-matched patients with systemic lupus erythematosus (SLE). When cultured with 26G11 cells, B cells from DR-matched normal control subjects produced large amounts of IgM anti-DNA antibody, but did not produce IgG anti-DNA antibody which is thought to have a pathological role in SLE. In contrast, B cells from DR-matched patients with active SLE spontaneously produced a fairly large amount of IgG anti-DNA antibody, and the production was augmented by the T cell clone. Little IgG anti-DNA antibody was produced by the B cells of patients with inactive SLE in either the presence or absence of T cell clone. We next fractionated B cells into low density B (LD-B) and high density B (HD-B) cells by centrifugation on discontinuous Percoll density gradients. IgG anti-DNA antibody was spontaneously produced by LD-B cells of active SLE patients but not by those either of inactive SLE patients or normal controls. On the other hand, although IgG anti-DNA antibody was not spontaneously produced by the HD-B cells of both active and inactive SLE patients, it could easily be induced by their culture with the T cell clone. Our results clearly show the existence of IgG anti-DNA antibody-producing B cells in the peripheral blood of SLE patients irrespective of their disease activity and suggest that autoreactive T cells may play a pathogenic role in SLE through the induction of autoantibody production. | lld:pubmed |
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| pubmed-article:1424281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1424281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1424281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1424281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1424281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1424281 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1424281 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1424281 | pubmed:author | pubmed-author:MurakamiMM | lld:pubmed |
| pubmed-article:1424281 | pubmed:author | pubmed-author:IwaiKK | lld:pubmed |
| pubmed-article:1424281 | pubmed:author | pubmed-author:ImuraHH | lld:pubmed |
| pubmed-article:1424281 | pubmed:author | pubmed-author:SugitaMM | lld:pubmed |
| pubmed-article:1424281 | pubmed:author | pubmed-author:KumagaiSS | lld:pubmed |
| pubmed-article:1424281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1424281 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:1424281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1424281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1424281 | pubmed:pagination | 245-50 | lld:pubmed |
| pubmed-article:1424281 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1424281 | pubmed:meshHeading | pubmed-meshheading:1424281-... | lld:pubmed |
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| pubmed-article:1424281 | pubmed:meshHeading | pubmed-meshheading:1424281-... | lld:pubmed |
| pubmed-article:1424281 | pubmed:meshHeading | pubmed-meshheading:1424281-... | lld:pubmed |
| pubmed-article:1424281 | pubmed:meshHeading | pubmed-meshheading:1424281-... | lld:pubmed |
| pubmed-article:1424281 | pubmed:meshHeading | pubmed-meshheading:1424281-... | lld:pubmed |
| pubmed-article:1424281 | pubmed:meshHeading | pubmed-meshheading:1424281-... | lld:pubmed |
| pubmed-article:1424281 | pubmed:meshHeading | pubmed-meshheading:1424281-... | lld:pubmed |
| pubmed-article:1424281 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1424281 | pubmed:articleTitle | In vitro induction of IgG anti-DNA antibody from high density B cells of systemic lupus erythematosus patients by an HLA DR-restricted T cell clone. | lld:pubmed |
| pubmed-article:1424281 | pubmed:affiliation | Second Division of Internal Medicine, School of Medicine, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:1424281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1424281 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1424281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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