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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5 Suppl
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pubmed:dateCreated |
1992-12-2
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pubmed:abstractText |
Both short- and long-term extracorporeal membrane oxygenation (ECMO) causes platelet loss and dysfunction. Bitistatin is a reversible inhibitor of the platelet glycoprotein IIb/IIIa receptor. This study tests the hypothesis that inhibition of platelets by bitistatin during initial contact with the perfusion circuit preserves platelet number and function during long-term ECMO in sheep.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-7322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
II398-404
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:1424031-Adenosine Diphosphate,
pubmed-meshheading:1424031-Animals,
pubmed-meshheading:1424031-Bleeding Time,
pubmed-meshheading:1424031-Blood Platelets,
pubmed-meshheading:1424031-Extracorporeal Membrane Oxygenation,
pubmed-meshheading:1424031-Peptides,
pubmed-meshheading:1424031-Platelet Aggregation Inhibitors,
pubmed-meshheading:1424031-Platelet Count,
pubmed-meshheading:1424031-Platelet Factor 4,
pubmed-meshheading:1424031-Platelet Membrane Glycoproteins,
pubmed-meshheading:1424031-Sheep,
pubmed-meshheading:1424031-Time Factors,
pubmed-meshheading:1424031-Viper Venoms
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pubmed:year |
1992
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pubmed:articleTitle |
Protection of platelets during long-term extracorporeal membrane oxygenation in sheep with a single dose of a disintegrin.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, School of Medicine, University of Pennsylvania, Philadelphia 19104.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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