Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-12-23
|
| pubmed:abstractText |
Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photomorphogenesis in darkness and that light reverses this repressive activity. Using a T-DNA-tagged mutant, we have cloned the COP1 locus. The amino-terminal half of the encoded protein contains a conserved zinc-binding motif, whereas the carboxyl-terminal half contains a domain homologous to the WD-40 repeat motif of G beta proteins. The presence of both a putative DNA-binding motif and a G protein-related domain in a single polypeptide suggests that COP1 may be the first of a new class of regulatory molecules. This novel structure could endow COP1 with the capacity to function as a negative transcriptional regulator capable of direct interaction with components of the G protein signaling pathway.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
71
|
| pubmed:geneSymbol |
RAD18,
RAG1,
Rpt1,
rbcS
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
791-801
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1423630-Amino Acid Sequence,
pubmed-meshheading:1423630-Arabidopsis,
pubmed-meshheading:1423630-Base Sequence,
pubmed-meshheading:1423630-Cell Differentiation,
pubmed-meshheading:1423630-Cloning, Molecular,
pubmed-meshheading:1423630-Consensus Sequence,
pubmed-meshheading:1423630-GTP-Binding Proteins,
pubmed-meshheading:1423630-Gene Expression,
pubmed-meshheading:1423630-Genes, Plant,
pubmed-meshheading:1423630-Genes, Regulator,
pubmed-meshheading:1423630-Light,
pubmed-meshheading:1423630-Microscopy, Electron, Scanning,
pubmed-meshheading:1423630-Molecular Sequence Data,
pubmed-meshheading:1423630-Oligodeoxyribonucleotides,
pubmed-meshheading:1423630-Polymerase Chain Reaction,
pubmed-meshheading:1423630-RNA, Messenger,
pubmed-meshheading:1423630-Restriction Mapping,
pubmed-meshheading:1423630-Sequence Alignment,
pubmed-meshheading:1423630-Zinc Fingers
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain.
|
| pubmed:affiliation |
University of California, Berkeley, United States Department of Agriculture Plant Gene Expression Center, Albany 94710.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|