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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-12-15
|
| pubmed:abstractText |
Intravenous injection of low doses of naloxone was found to reverse the respiratory depression induced by apomorphine in chloralose-anesthesized dogs. Similar results were obtained with haloperidol, whereas yohimbine remained ineffective. These data suggest that apomorphine depresses respiratory rate through a mechanism involving both dopamine and opiate mechanisms but not alpha 2-adrenoceptors. Respiratory arrest induced by overdosages of apomorphine can be treated with naloxone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0362-5664
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
404-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1423340-Animals,
pubmed-meshheading:1423340-Apomorphine,
pubmed-meshheading:1423340-Dogs,
pubmed-meshheading:1423340-Drug Interactions,
pubmed-meshheading:1423340-Female,
pubmed-meshheading:1423340-Haloperidol,
pubmed-meshheading:1423340-Injections, Intravenous,
pubmed-meshheading:1423340-Male,
pubmed-meshheading:1423340-Naloxone,
pubmed-meshheading:1423340-Respiratory Insufficiency,
pubmed-meshheading:1423340-Vomiting,
pubmed-meshheading:1423340-Yohimbine
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Naloxone or haloperidol but not yohimbine reverse apomorphine-induced respiratory depression.
|
| pubmed:affiliation |
Laboratoire de Pharmacologie Médicale et Clinique, INSERM U317, Faculté de Médecine, Toulouse, France.
|
| pubmed:publicationType |
Journal Article
|