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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-12-4
pubmed:abstractText
The topographical distribution of cholinergic muscarinic receptor (MChR) sites was studied by means of quantitative receptor autoradiography using [3H]quinuclidinyl benzilate ([3H]QNB) in the frontal (prefrontal, premotor and motor) cortex of the dog. The mean binding value in the frontal cortex was 408 +/- 5.0 fmol/mg tissue and the only area that differed significantly from the mean was the primary motor cortex, where the binding value was significantly lower. In the dorsal part of the prefrontal and premotor cortical subregions studied, a tri-laminar pattern of [3H]QNB labelling was observed, with a superficial dense band of label corresponding to cortical layers I, II and III. The deep high density band overlaid layer V and the upper part of the layer VI. In the ventral part of the prefrontal cortex this pattern gradually disappeared and in the most ventral part no laminar differences were seen. In contrast, in primary motor areas, the deep band of labelling corresponding to layer V was much less pronounced than in the frontal association cortex. Variations in the distribution of MChR sites seem to reflect to some extent the greater cytoarchitectonic differentiation of the dorsal zone and also the similarity between the ventral zone and the limbic cortex described by us previously.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0891-0618
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
The distribution of cholinergic muscarinic receptors in the dog frontal lobe.
pubmed:affiliation
Department of Neurophysiology, Nencki Institute, Warsaw, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't