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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-11-18
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pubmed:abstractText |
Fifteen non-obese patients with familial hypercholesterolemia and fifteen normocholesterolemic subjects matched for age, body mass index, waist/hip ratio, arterial blood pressure and sedentary life style underwent blood sampling for determination of fasting plasma glucose, insulin, total-, LDL-, HDL-cholesterol, triglycerides, free fatty acids, apolipoprotein A1 and B. In both groups of subjects we determined erythrocyte membrane microviscosity and performed an echocardiographic study. We demonstrated that hypercholesterolemic patients had a significant increase in fasting plasma total cholesterol (8.9 +/- 0.5 vs. 5.5 +/- 0.3 mmol/l, P less than 0.001), insulin (79 +/- 4 vs. 58 +/- 4 pmol/l, P less than 0.05) and apolipoprotein B (2.2 +/- 0.5 vs. 1.3 +/- 0.5 g/l P less than 0.01). In the echocardiographic study we found a significant impairment in left ventricular relaxation (isovolumic relaxation time (IRT) 106 +/- 6 vs. 73 +/- 7 ms, P less than 0.01). Erythrocyte membrane microviscosity (0.253 +/- 0.004 vs. 0.225 +/- 0.003, P less than 0.05) was also increased in hypercholesterolemic patients. Finally we found that erythrocyte membrane microviscosity correlated with fasting plasma insulin levels (r = -0.46, P less than 0.03) and IRT (r = -0.52, P less than 0.01).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-70
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1418103-Adult,
pubmed-meshheading:1418103-Blood Glucose,
pubmed-meshheading:1418103-Echocardiography,
pubmed-meshheading:1418103-Erythrocyte Membrane,
pubmed-meshheading:1418103-Female,
pubmed-meshheading:1418103-Glucose Tolerance Test,
pubmed-meshheading:1418103-Humans,
pubmed-meshheading:1418103-Hyperlipoproteinemia Type II,
pubmed-meshheading:1418103-Insulin,
pubmed-meshheading:1418103-Lipids,
pubmed-meshheading:1418103-Male,
pubmed-meshheading:1418103-Membrane Fluidity,
pubmed-meshheading:1418103-Myocardial Contraction,
pubmed-meshheading:1418103-Ventricular Function, Left
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pubmed:year |
1992
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pubmed:articleTitle |
Impaired left ventricular relaxation and hyperinsulinemia in patients with primary hypercholesterolemia.
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pubmed:affiliation |
Department of Geriatric Medicine, and Metabolic Diseases, 1st Medical School, University of Naples, Italy.
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pubmed:publicationType |
Journal Article
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