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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1992-10-30
|
| pubmed:abstractText |
Stereoselective pharmacokinetic properties of chloroquine (CAS 54-05-7) and desethylchloroquine were investigated in rabbits by administration of the separate enantiomers according to a cross-over design. The terminal half-life was longer for (R)-chloroquine than for (S)-chloroquine. A striking difference was revealed in the concentrations of metabolites. The levels of (R)-desethylchloroquine were higher than those of (S)-desethylchloroquine, resulting in a statistically significant higher AUC for the (R)-metabolite than for the (S)-metabolite.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0004-4172
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
825-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1418039-Animals,
pubmed-meshheading:1418039-Chloroquine,
pubmed-meshheading:1418039-Female,
pubmed-meshheading:1418039-Half-Life,
pubmed-meshheading:1418039-Injections, Intramuscular,
pubmed-meshheading:1418039-Male,
pubmed-meshheading:1418039-Rabbits,
pubmed-meshheading:1418039-Stereoisomerism,
pubmed-meshheading:1418039-Tissue Distribution
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Stereoselectivity in the disposition of chloroquine and desethylchloroquine in rabbits.
|
| pubmed:affiliation |
Laboratory of Clinical Pharmacy, University of Leuven, Belgium.
|
| pubmed:publicationType |
Journal Article
|