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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-11-23
|
| pubmed:abstractText |
Secretion of the lysosomal enzyme beta-N-acetylhexosaminidase is inhibited by calcium ionophore A-23187 in the GG2EE macrophage cell line. Such inhibition is time and dose dependent. Calcium ionophore A-23187 treatment causes a change in the pattern of hexosaminidase isoenzymes detectable in the cell extract, as assessed by DEAE-cellulose chromatography. In particular, control cells show two hexosaminidase isoenzymes corresponding to hexosaminidase A and B, whereas cells treated with calcium ionophore A-23187 express a third isoenzyme form with properties similar to hexosaminidase S.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0158-5231
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
783-91
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1417912-Animals,
pubmed-meshheading:1417912-Calcimycin,
pubmed-meshheading:1417912-Cell Line,
pubmed-meshheading:1417912-Chromatography, DEAE-Cellulose,
pubmed-meshheading:1417912-Hexosaminidase A,
pubmed-meshheading:1417912-Isoenzymes,
pubmed-meshheading:1417912-Macrophages,
pubmed-meshheading:1417912-Mice,
pubmed-meshheading:1417912-beta-N-Acetylhexosaminidases
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Calcium ionophore A-23187 inhibits the secretion of beta-hexosaminidase from the GG2EE mouse macrophage cell line.
|
| pubmed:affiliation |
Dipartimento di Medicina Sperimentale e Scienze Biochemiche, Università di Perugia, Italia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|