|
rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
9
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pubmed:dateCreated |
1992-11-3
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|
pubmed:abstractText |
The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies against the nucleo-histone complex (H2A-H2B)-DNA. After a short course of treatment with prednisone and discontinuation of isoniazid the patient's lupus symptoms resolved and a gradual decrease in antibodies to (H2A-H2B)-DNA occurred. This case suggests that isoniazid is capable of inducing an autoantibody specificity associated with drug related lupus.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0003-4967
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
51
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1085-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1417144-Aged,
pubmed-meshheading:1417144-Antibodies, Antinuclear,
pubmed-meshheading:1417144-Histones,
pubmed-meshheading:1417144-Humans,
pubmed-meshheading:1417144-Immunoglobulin G,
pubmed-meshheading:1417144-Isoniazid,
pubmed-meshheading:1417144-Lupus Erythematosus, Systemic,
pubmed-meshheading:1417144-Male,
pubmed-meshheading:1417144-Prednisone
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|
pubmed:year |
1992
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|
pubmed:articleTitle |
Systemic lupus erythematosus induced by isoniazid.
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|
pubmed:affiliation |
Department of Immunology and Rheumatology, Hospital General de Occidente de la S.S., Zapopan, Jalisco, Mexico.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
