Switch to
Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-11-10
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pubmed:abstractText |
Immunohistochemical staining techniques used on an 11-week-old fetus showed that fetal antigen 2 (FA2) was present intracellularly in endochondral and perichondral osteoblasts, and the immunoreaction was extended into the adjacent bone matrix. Osteoclasts and chondroblasts were found to be FA2 negative. A granular perinuclear intracytoplasmic FA2 immunoreaction was found in cultured osteoblasts and osteogenic osteosarcoma cells, and immunoelectron-microscopical examination revealed a granular immunoreaction product in the rough endoplasmic reticulum. These findings indicate that FA2 is synthesized by osteoblasts and osteogenic osteosarcoma cells. A reaction of immunological identity was found between FA2 purified from second trimester amniotic fluid and serum-free supernatants of cultured osteogenic osteosarcoma cells. This shows that an antigen recognized by the anti FA2 antibody is secreted by these malignant cells. Thus, FA2 may represent a marker for altered bone metabolism, and have a potential in the classification of osteogenic osteosarcoma/chondrosarcoma.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0340-2061
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1416076-Bone and Bones,
pubmed-meshheading:1416076-Cells, Cultured,
pubmed-meshheading:1416076-Collagen Type I,
pubmed-meshheading:1416076-Fetal Proteins,
pubmed-meshheading:1416076-Fetus,
pubmed-meshheading:1416076-Humans,
pubmed-meshheading:1416076-Microscopy, Immunoelectron,
pubmed-meshheading:1416076-Neoplasm Proteins,
pubmed-meshheading:1416076-Osteoblasts,
pubmed-meshheading:1416076-Osteosarcoma,
pubmed-meshheading:1416076-Tumor Cells, Cultured
|
pubmed:year |
1992
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pubmed:articleTitle |
Fetal antigen 2 (FA2) in human fetal osteoblasts, cultured osteoblasts and osteogenic osteosarcoma cells.
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pubmed:affiliation |
Department of Human Anatomy, Odense University, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|