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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1992-11-20
|
| pubmed:abstractText |
Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. PQ (100 microM) potentiated IL-1 production (2-40 fold) and TNF production (2-18 fold). It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0065-4299
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
66-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1414690-Antibody Specificity,
pubmed-meshheading:1414690-Cross Reactions,
pubmed-meshheading:1414690-Humans,
pubmed-meshheading:1414690-Interleukin-1,
pubmed-meshheading:1414690-Lipopolysaccharides,
pubmed-meshheading:1414690-Monocytes,
pubmed-meshheading:1414690-Paraquat,
pubmed-meshheading:1414690-Radioimmunoassay,
pubmed-meshheading:1414690-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
The pneumotoxicant paraquat potentiates IL-1 and TNF production by human mononuclear cells.
|
| pubmed:affiliation |
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|