Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-10-29
pubmed:abstractText
Cerebrospinal fluid (CSF) and serum samples of 20 patients with central nervous system manifestations of hematological malignancies including primary cerebral lymphoma (n = 5) and disseminated non-Hodgkin lymphoma (n = 7) were examined for albumin, IgG, IgM, fibronectin, beta 2-microglobulin, interleukin-6, soluble interleukin-2 receptor, tumor necrosis factor alpha, and oligoclonal immunoglobulin bands. Although a broad range of abnormalities were detected, no reliable CSF parameter for the diagnosis of leptomeningeal spread from hematological neoplasias could be identified. An analysis of 61 repeat lumbar punctures added little to the findings of the first CSF examinations. Currently, immunochemical studies of CSF cell surface markers and early biopsy have probably more clinical value than the determination of the humoral CSF parameters included in this study. However, analysis of cytokine synthesis by single CSF cells using molecular biology techniques may improve the differential diagnosis of hematological neoplasia of the brain and spinal cord in the future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0001-6314
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-33
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:1414221-Blood-Brain Barrier, pubmed-meshheading:1414221-Cerebrospinal Fluid, pubmed-meshheading:1414221-Hodgkin Disease, pubmed-meshheading:1414221-Humans, pubmed-meshheading:1414221-Immunoglobulin G, pubmed-meshheading:1414221-Immunoglobulin M, pubmed-meshheading:1414221-Interleukin-6, pubmed-meshheading:1414221-Leukemia, Myeloid, Acute, pubmed-meshheading:1414221-Leukemic Infiltration, pubmed-meshheading:1414221-Lymphoma, Non-Hodgkin, pubmed-meshheading:1414221-Meningeal Neoplasms, pubmed-meshheading:1414221-Meninges, pubmed-meshheading:1414221-Multiple Myeloma, pubmed-meshheading:1414221-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:1414221-Receptors, Interleukin-2, pubmed-meshheading:1414221-Serum Albumin, pubmed-meshheading:1414221-Tumor Markers, Biological, pubmed-meshheading:1414221-Tumor Necrosis Factor-alpha, pubmed-meshheading:1414221-beta 2-Microglobulin
pubmed:year
1992
pubmed:articleTitle
Humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia.
pubmed:affiliation
Department of Neurology, University of Tübingen, Germany.
pubmed:publicationType
Journal Article