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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1992-11-4
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pubmed:abstractText |
Solid cell nests (SCN) are found within the thyroid parenchyma on routine clinical pathological examinations, but their histogenesis and clinical significance are still obscure. From November 1987 to May 1991, a total of 3,260 patients underwent thyroid surgery at Ito Hospital and SCN were noted in 42 (1.3%) patients. Serial sections of the specimens from these patients were studied morphologically and immunohistochemically. The location and growth pattern of SCN within the thyroid parenchyma were distinct from those of hyperplastic C-cells. SCN were located in the isthmus lobe in 1 patient and even in the pyramidal lobe in 3 patients. In another patient neoplastic proliferation of SCN was observed. Immunohistochemically, SCN were negative for neuron-specific enolase, chromogranin A, and S-100 protein. These findings strongly suggest that SCN are of endodermal origin and that they may be closely related to mucoepidermoid carcinoma of the thyroid gland.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
0364-2313
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
685-8; discussion 688-9
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:1413837-Adenocarcinoma,
pubmed-meshheading:1413837-Adult,
pubmed-meshheading:1413837-Aged,
pubmed-meshheading:1413837-Carcinoma,
pubmed-meshheading:1413837-Carcinoma, Papillary,
pubmed-meshheading:1413837-Female,
pubmed-meshheading:1413837-Graves Disease,
pubmed-meshheading:1413837-Humans,
pubmed-meshheading:1413837-Male,
pubmed-meshheading:1413837-Middle Aged,
pubmed-meshheading:1413837-Precancerous Conditions,
pubmed-meshheading:1413837-Thyroid Diseases,
pubmed-meshheading:1413837-Thyroid Gland,
pubmed-meshheading:1413837-Thyroid Neoplasms
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pubmed:articleTitle |
Solid cell nests of the thyroid gland: precursor of mucoepidermoid carcinoma?
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pubmed:affiliation |
Surgery Branch, Ito Hospital, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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