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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-11-16
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pubmed:abstractText |
The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
191
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1413526-Animals,
pubmed-meshheading:1413526-Cells, Cultured,
pubmed-meshheading:1413526-Coronaviridae,
pubmed-meshheading:1413526-Cricetinae,
pubmed-meshheading:1413526-Giant Cells,
pubmed-meshheading:1413526-Humans,
pubmed-meshheading:1413526-Membrane Glycoproteins,
pubmed-meshheading:1413526-Mice,
pubmed-meshheading:1413526-Rabbits,
pubmed-meshheading:1413526-Receptors, Virus,
pubmed-meshheading:1413526-Viral Envelope Proteins,
pubmed-meshheading:1413526-Virus Replication
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pubmed:year |
1992
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pubmed:articleTitle |
Cell receptor-independent infection by a neurotropic murine coronavirus.
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pubmed:affiliation |
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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