| pubmed-article:1412748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1412748 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1412748 | lifeskim:mentions | umls-concept:C0332835 | lld:lifeskim |
| pubmed-article:1412748 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:1412748 | lifeskim:mentions | umls-concept:C0205223 | lld:lifeskim |
| pubmed-article:1412748 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1412748 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:1412748 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1412748 | pubmed:dateCreated | 1992-11-13 | lld:pubmed |
| pubmed-article:1412748 | pubmed:abstractText | Allogeneic islets encapsulated in an alginate/poly-L-lysine membrane and transplanted into diabetic BB/W rats resulted in graft failure within 2 weeks of transplantation. Graft failure was associated with a dense pericapsular infiltrate (PCI) that resulted in necrosis of the encapsulated islets. The PCI could be inhibited by immunosuppressive agents, including cyclosporine and dexamethasone, and this resulted in a significant increase in graft survival. Immunopathological characterization of the PCI indicated that there was a predominance of macrophages. T helper cells also appeared to be present in this PCI. Empty capsules were also found to induce a similar PCI that was identical in composition to that found around encapsulated islets. Thus alginate/poly-L-lysine capsules do not appear to be biocompatible and may account for the variable results in islet graft survival found with these capsules. | lld:pubmed |
| pubmed-article:1412748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1412748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1412748 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1412748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1412748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1412748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1412748 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1412748 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:GarciaBB | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:StillerCC | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:PaulTT | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:VoseJJ | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:AtkisonPP | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:O'SheaGG | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:MazaheriRR | lld:pubmed |
| pubmed-article:1412748 | pubmed:author | pubmed-author:WijsmanJJ | lld:pubmed |
| pubmed-article:1412748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1412748 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:1412748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1412748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1412748 | pubmed:pagination | 588-92 | lld:pubmed |
| pubmed-article:1412748 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:meshHeading | pubmed-meshheading:1412748-... | lld:pubmed |
| pubmed-article:1412748 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1412748 | pubmed:articleTitle | Histological and immunopathological analysis of recovered encapsulated allogeneic islets from transplanted diabetic BB/W rats. | lld:pubmed |
| pubmed-article:1412748 | pubmed:affiliation | University of Western Ontario, London, Canada. | lld:pubmed |
| pubmed-article:1412748 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1412748 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
