Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1992-11-13
|
pubmed:abstractText |
Allogeneic islets encapsulated in an alginate/poly-L-lysine membrane and transplanted into diabetic BB/W rats resulted in graft failure within 2 weeks of transplantation. Graft failure was associated with a dense pericapsular infiltrate (PCI) that resulted in necrosis of the encapsulated islets. The PCI could be inhibited by immunosuppressive agents, including cyclosporine and dexamethasone, and this resulted in a significant increase in graft survival. Immunopathological characterization of the PCI indicated that there was a predominance of macrophages. T helper cells also appeared to be present in this PCI. Empty capsules were also found to induce a similar PCI that was identical in composition to that found around encapsulated islets. Thus alginate/poly-L-lysine capsules do not appear to be biocompatible and may account for the variable results in islet graft survival found with these capsules.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0041-1337
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
54
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
588-92
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1412748-Animals,
pubmed-meshheading:1412748-Cyclosporine,
pubmed-meshheading:1412748-Dexamethasone,
pubmed-meshheading:1412748-Drug Compounding,
pubmed-meshheading:1412748-Graft Survival,
pubmed-meshheading:1412748-Islets of Langerhans Transplantation,
pubmed-meshheading:1412748-Liver,
pubmed-meshheading:1412748-Male,
pubmed-meshheading:1412748-Rats,
pubmed-meshheading:1412748-Rats, Inbred BB,
pubmed-meshheading:1412748-Stomach,
pubmed-meshheading:1412748-Transplantation, Homologous
|
pubmed:year |
1992
|
pubmed:articleTitle |
Histological and immunopathological analysis of recovered encapsulated allogeneic islets from transplanted diabetic BB/W rats.
|
pubmed:affiliation |
University of Western Ontario, London, Canada.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|