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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0001927,
umls-concept:C0008565,
umls-concept:C0032105,
umls-concept:C0185125,
umls-concept:C0220825,
umls-concept:C0443315,
umls-concept:C0680730,
umls-concept:C1148554,
umls-concept:C1185738,
umls-concept:C1510438,
umls-concept:C1533685,
umls-concept:C1555707,
umls-concept:C1704970,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
3
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pubmed:dateCreated |
1992-11-4
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pubmed:abstractText |
An isocratic high-performance liquid chromatography method with amperometric detection for the assay of plasma salbutamol is described. The plasma extract is injected into the chromatographic system via a loop column. This insures the purification of the injected extracts and allows a simple and rapid liquid-solid extraction procedure. The good reliability, as shown by the low limit of detection (0.5 ng/ml) and a precision ranging between 5 and 10%, has permitted the investigation of a new mode of administration of salbutamol using a portable subcutaneous infusion pump. Our results show that subcutaneous administration yields plasma levels comparable with those obtained after usual intravenous doses.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0163-4356
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1412610-Albuterol,
pubmed-meshheading:1412610-Chromatography, High Pressure Liquid,
pubmed-meshheading:1412610-Chromatography, Ion Exchange,
pubmed-meshheading:1412610-Electrochemistry,
pubmed-meshheading:1412610-Female,
pubmed-meshheading:1412610-Fenoterol,
pubmed-meshheading:1412610-Humans,
pubmed-meshheading:1412610-Infusion Pumps,
pubmed-meshheading:1412610-Injections, Subcutaneous,
pubmed-meshheading:1412610-Pregnancy
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pubmed:year |
1992
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pubmed:articleTitle |
Plasma assay of salbutamol by means of high-performance liquid chromatography with amperometric determination using a loop column for injection of plasma extracts. Application to the evaluation of subcutaneous administration of salbutamol.
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pubmed:affiliation |
Laboratory of Pharmacokinetics and Toxicology, Ambroise Paré Hospital, Boulogne, France.
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pubmed:publicationType |
Journal Article
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