|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1992-11-13
|
|
pubmed:abstractText |
HLA-DR4 has been described in association with rheumatoid arthritis (RA) in multiple populations. We have studied HLA antigens in Alaskan Tlingit Indians. HLA-DR4 was decreased in the RA group (n = 32) compared with controls (n = 62) (6% vs 21% p = 0.07). The predominant DR4 allele observed was DRB1*0403 (Dw13.1). The most striking observation in these studies was a marked predominance of the DRB1*1402 allele encoding Dw16 (DRw14). This allele was present in 91% of RA cases, but was also highly prevalent in controls (80%, OR = 2.4 p = 0.20). DRB1*1402 only was observed in 47% of cases and 31% of controls. The DRB3*0101 (DRw52), and the DQA*0501 and DQB*0301 alleles encoding a subset of DQw3 were associated with DRB1*1402 in cases and in controls. HLA-Bw62 was increased in RA cases (28%) compared with controls (8%) (OR = 4.5, p = 0.01, corrected p = ns).
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0001-2815
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
40
|
|
pubmed:geneSymbol |
HLA-A,
HLA-B,
HLA-C,
HLA-DQ,
HLA-DR
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
57-63
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1412417-Adult,
pubmed-meshheading:1412417-Aged,
pubmed-meshheading:1412417-Alaska,
pubmed-meshheading:1412417-Alleles,
pubmed-meshheading:1412417-Arthritis, Rheumatoid,
pubmed-meshheading:1412417-DNA,
pubmed-meshheading:1412417-Female,
pubmed-meshheading:1412417-HLA Antigens,
pubmed-meshheading:1412417-HLA-A Antigens,
pubmed-meshheading:1412417-HLA-B Antigens,
pubmed-meshheading:1412417-HLA-C Antigens,
pubmed-meshheading:1412417-HLA-DQ Antigens,
pubmed-meshheading:1412417-HLA-DR Antigens,
pubmed-meshheading:1412417-Humans,
pubmed-meshheading:1412417-Indians, North American,
pubmed-meshheading:1412417-Male,
pubmed-meshheading:1412417-Middle Aged,
pubmed-meshheading:1412417-Oligonucleotide Probes,
pubmed-meshheading:1412417-Prevalence,
pubmed-meshheading:1412417-Statistics as Topic
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
HLA antigens in Tlingit Indians with rheumatoid arthritis.
|
|
pubmed:affiliation |
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
