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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-11-4
|
| pubmed:abstractText |
The carcinogenic potential of prednisone, a synthetic corticosteroid used as an anti-inflammatory and immunosuppressive agent, was investigated by feeding it to Crl:CD-1(ICR) mice (50/sex/dose) at doses of 0.25, 0.50, 1.0, and 5.0 mg/kg/day for 18 months. Prednisone did not significantly increase the incidence of neoplasms (p less than or equal to 0.05); on the contrary, it significantly decreased the incidence of hepatocellular tumors (p = 0.002 in males, p = 0.027 in females), male lacrimal/Harderian gland tumors (p = 0.05), female pulmonary adenomas (p = 0.047), female endothelial cell tumors (p = 0.035), and female lymphosarcomas (p = 0.02). This study suggests that long-term (lifetime) prednisone use does not increase cancer risk and may actually reduce it.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0192-6233
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
18-26
|
| pubmed:dateRevised |
2009-7-1
|
| pubmed:meshHeading |
pubmed-meshheading:1411127-Animals,
pubmed-meshheading:1411127-Blood Cell Count,
pubmed-meshheading:1411127-Body Weight,
pubmed-meshheading:1411127-Carcinogens,
pubmed-meshheading:1411127-Female,
pubmed-meshheading:1411127-Male,
pubmed-meshheading:1411127-Mice,
pubmed-meshheading:1411127-Mice, Inbred ICR,
pubmed-meshheading:1411127-Neoplasms, Experimental,
pubmed-meshheading:1411127-Prednisone
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Prednisone is not a mouse carcinogen.
|
| pubmed:affiliation |
Toxicology Department-Indianapolis Center, Marion Merrell Dow Inc., Indiana 46268-0470.
|
| pubmed:publicationType |
Journal Article
|