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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-11-5
|
| pubmed:abstractText |
Severe necrotizing pancreatitis is accompanied by release of hemorrhagic ascites fluid (HAF), which is thought to be related to the occurrence and frequency of cardiocirculatory and pulmonary failure as a consequence of acute pancreatitis. The purpose of this study was to evaluate the role of HAF due to these systemic complications. Experiments were performed in 25 pigs (mean b.wt. 22 +/- 1 kg) under general anesthesia and mechanical ventilation. The animals received 50 ml/kg b.wt. i.p. of either physiologic saline solution (control CO, n = 9) or hemorrhagic ascites fluid (HAF, n = 16). HAF was obtained from 16 pigs with pancreatitis induced by intraductal infusion of bile salt. Eight animals in the HAF group were pretreated with indomethacin (10 mg/kg i.v. INDO/HAF). All animals were followed up for 6 h. Mean arterial pressure, cardiac output, and stroke volume fell significantly in the HAF (-25%, -27%, -27%) and in the INDO/HAF groups (-24%, -20%, -17%) as compared with controls (-6%, -6%, -6%). Also, left ventricular end-diastolic pressure (LVEDP) decreased by 52% and 48% in both HAF recipient groups, whereas LVEDP was unchanged in the control group. Myocardial contractility (Vmax) remained unaltered in all experimental groups. No significant differences in gas exchange and lung dry/wet weight ratio were observed. Lipase and PGI2 of the unpretreated HAF group rised to 203% and 198% in arterial blood at 6 h compared with unaltered levels in the control group. No increase of prostanoid concentrations was detected in the indomethacin-pretreated group, whereas lipase increase by a comparable extent as in the HAF group. We conclude that the early consequences of HAF are mainly characterized by systemic hypotension due to hypovolemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-9130
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
192
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
269-79
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1410801-Acute Disease,
pubmed-meshheading:1410801-Animals,
pubmed-meshheading:1410801-Ascitic Fluid,
pubmed-meshheading:1410801-Disease Models, Animal,
pubmed-meshheading:1410801-Extravascular Lung Water,
pubmed-meshheading:1410801-Hemodynamics,
pubmed-meshheading:1410801-Hypotension,
pubmed-meshheading:1410801-Indomethacin,
pubmed-meshheading:1410801-Infusions, Parenteral,
pubmed-meshheading:1410801-Myocardial Contraction,
pubmed-meshheading:1410801-Pancreatitis,
pubmed-meshheading:1410801-Plasma Volume,
pubmed-meshheading:1410801-Pulmonary Gas Exchange,
pubmed-meshheading:1410801-Swine
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Hemodynamic effects following intraperitoneal infusion of pancreatic ascites fluid.
|
| pubmed:affiliation |
Institute of Surgical Research, Ludwig-Maximilians-Universität, München, Federal Republic of Germany.
|
| pubmed:publicationType |
Journal Article
|