Linked Life Data

1409943

Source:http://linkedlifedata.com/resource/pubmed/id/1409943

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-11-23
pubmed:abstractText
This study examined the metabolic mechanisms involved in the impaired insulin secretion by pancreatic islets isolated from fasted and exercised rats. Insulin secretion to glucose (8.3 to 16.7 mM) stimulus was lower in fasted (F), exercised (E), and fasted plus exercised (EF) rats as compared with the control group. The rate of glucose oxidation by isolated islets was reduced in F and EF rats, but it was not modified in the E group. In response to alpha-KIC (5, 10, 15, and 20 mM), insulin secretion was not different in EF and F rats, in comparison to controls, except in the E group, which showed values slightly higher. These findings suggest that changes in insulin secretion in fasted rats, associated or not to exercise training, might be a consequence of a reduced activity of the right-hand side of the Krebs cycle (from pyruvate to oxoglutarate), leading to decreased glucose oxidation. However, the exercise itself caused a significant decrease of insulin secretion without altering glycolysis and Krebs cycle activities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
723-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Metabolic mechanisms involved in the impaired insulin secretion in pancreatic islets isolated from exercised and fasted rats.
pubmed:affiliation
Department of Physiology and Biophysics, University of São Paulo, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't