Linked Life Data

1409924

Source:http://linkedlifedata.com/resource/pubmed/id/1409924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-11-10
pubmed:abstractText
It has been proposed that increased glucocorticoid hormones and decreased sex hormones affect regional fat metabolism and distribution. In the present work, it was hypothesized that chronic, uncontrollable stress, known to affect the pituitary-adrenal and pituitary-gonadal axes might, therefore, lead to differences in regional fat accumulation. In comparison with controls, male Sprague-Dawley rats stressed for 28 days, had significantly larger adipocytes. In addition, a tendency for a heavier fat pad and an increased lipoprotein lipase activity in the mesenteric depot was suggested. No significant changes were seen in epididymal, retroperitoneal, and inguinal regions. In order to study if the effects observed could be attributed to increased glucocorticoids, the response to a direct administration of supraphysiological doses of corticosterone, given either in the drinking water or via subcutaneous implantation of corticosterone pellets, was studied. Increased fat accumulation was shown in all fat depots in a dose-response fashion, but was significantly more pronounced in the mesenteric region. It was concluded that mesenteric fat tissue may respond to stress in a different manner from other fat depots. Glucocorticoids seem to be partly, but not solely, responsible for the changes observed in adipose tissue metabolism and distribution following exposure to uncontrollable stress.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
583-90
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism.
pubmed:affiliation
Department of Psychology, Yale University, New Haven, CT 06520.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't