|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1992-11-4
|
|
pubmed:abstractText |
The utilization of calcium alginate beads as core carriers for delayed dissolution followed by burst release as a potential method of intestinal site specific drug delivery was investigated. 5-Aminosalicylic acid was spray-coated on dried calcium alginate beads and then coated with different percentages of enteric coating polymer and/or sustained-release polymer. Beads coated with more than 6% (w/w) methacrylic copolymer plastisized with dibutyl sebacate and triethyl citrate resisted release in 2-hr acid fluid challenge and allowed immediate dissolution upon transfer to simulated intestinal fluid. With 6% (w/w) methacrylic copolymer on top of 4% (w/w) ethylcellulose polymer, the major portion of drug did not release in 2 hr of acid treatment or the next 3 hr of simulated intestinal fluid treatment. This dosage form provides the possibility to deliver drug to the lower intestinal tract with minimal early release, followed by sustained release in the colon.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0724-8741
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1128-31
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:1409392-Alginates,
pubmed-meshheading:1409392-Aminosalicylic Acids,
pubmed-meshheading:1409392-Delayed-Action Preparations,
pubmed-meshheading:1409392-Drug Carriers,
pubmed-meshheading:1409392-Drug Delivery Systems,
pubmed-meshheading:1409392-Glucuronic Acid,
pubmed-meshheading:1409392-Hexuronic Acids,
pubmed-meshheading:1409392-Intestines,
pubmed-meshheading:1409392-Mesalamine,
pubmed-meshheading:1409392-Microspheres,
pubmed-meshheading:1409392-Polymers,
pubmed-meshheading:1409392-Solubility
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Calcium alginate beads as core carriers of 5-aminosalicylic acid.
|
|
pubmed:affiliation |
College of Pharmacy, Oregon State University, Corvallis 97331.
|
|
pubmed:publicationType |
Journal Article
|
