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Precipitins have been produced in the rabbit by injecting protein polysaccharide from bovine nasal cartilage in Freund's adjuvant. These antibodies did not precipitate either protein polysaccharides extracted from other species, or the separated protein and carbohydrate moieties of the antigen. It is postulated that the antibodies are directed toward determinants consisting of carbohydrate and amino acid residues linked in three-dimensional arrangements specific for different protein polysaccharides.
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