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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-10-30
|
| pubmed:abstractText |
Previous studies have shown that pyridostigmine (PD) is capable of increasing the growth hormone (GH) response to GH-releasing hormone (GHRH) in young healthy subjects. In order to investigate the influence of age and sex on the PD potentiation of GHRH-induced GH release, we have studied the GH response to GHRH (50 micrograms i.v.) 1 h after oral administration of placebo or PD (60 mg) in 8 young healthy men (aged 19-28 years) and 8 age-matched young women (aged 18-25 years) during the follicular phase of the menstrual cycle, as well as in 8 postmenopausal women (aged 57-62 years) and 8 age-matched elderly men (aged 56-64 years). In the same subjects the effect of PD alone (60 mg p.o.) was also studied. Furthermore, in 6 postmenopausal women and 6 elderly men, the effect of a 30-mg PD oral dose on GH secretion and GH response to GHRH was evaluated with a similar protocol. The GH responses (mean +/- SE) to GHRH + placebo were similar in young men (peak 20.1 +/- 2 ng/ml, AUC 1,250 +/- 113 ng/ml/min) and women (peak 29.3 +/- 2.3 ng/ml, AUC 1,769 +/- 305 ng/ml/min). PD 60 mg was capable of significantly increasing the GH response to GHRH in young men (peak 43.5 +/- 5.1 ng/ml, AUC 3,734 +/- 472 ng/ml/min, p less than 0.005) but not in women (peak 39 +/- 2.3 ng/ml, AUC 2,479 +/- 205 ng/ml/min).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0028-3835
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
208-13
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1407375-Adolescent,
pubmed-meshheading:1407375-Adult,
pubmed-meshheading:1407375-Aging,
pubmed-meshheading:1407375-Drug Synergism,
pubmed-meshheading:1407375-Female,
pubmed-meshheading:1407375-Growth Hormone,
pubmed-meshheading:1407375-Growth Hormone-Releasing Hormone,
pubmed-meshheading:1407375-Humans,
pubmed-meshheading:1407375-Kinetics,
pubmed-meshheading:1407375-Male,
pubmed-meshheading:1407375-Menopause,
pubmed-meshheading:1407375-Middle Aged,
pubmed-meshheading:1407375-Pyridostigmine Bromide,
pubmed-meshheading:1407375-Sex Characteristics
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Effects of sex and age on pyridostigmine potentiation of growth hormone-releasing hormone-induced growth hormone release.
|
| pubmed:affiliation |
Institute of Endocrinology, Catholic University School of Medicine, Rome, Italy.
|
| pubmed:publicationType |
Journal Article
|