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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1992-11-25
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pubmed:abstractText |
We studied the effect of ursodeoxycholic acid in 19 patients with primary biliary cirrhosis, mainly stages III and IV. The dose of UDCA employed was 10-15 mg/kg body weight per day. After 1 yr, 17 patients were still using UDCA, and the mean values of serum alkaline phosphatase, gamma-glutamyltranspeptidase and alanine-aminotransferase had fallen significantly. Serum bilirubin, initially elevated in 7 of the 13 late-stage (III and IV) patients, showed a further increase in 3 of the 7 patients. In 2 of these 3 patients, UDCA had to be withdrawn (dose reduction had no effect). One patient developed a decompensated cirrhosis in spite of UDCA withdrawal. Pruritus worsened in 4 patients, all of whom were late stage patients. Ten late-stage (III-IV) patients showed improvement in liver biochemistry and clinical findings as did all early-stage PBC patients. Thus, UDCA treatment is not beneficial for all PBC patients. Special care should be taken in the early phase of UDCA therapy in later-stage (III-IV) patients: frequent biochemical checks should be carried out, for instance every 2 weeks in the first 2 months after starting UDCA, especially the estimation of bilirubin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0300-2977
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1407234-Adult,
pubmed-meshheading:1407234-Aged,
pubmed-meshheading:1407234-Female,
pubmed-meshheading:1407234-Humans,
pubmed-meshheading:1407234-Liver Cirrhosis, Biliary,
pubmed-meshheading:1407234-Liver Function Tests,
pubmed-meshheading:1407234-Male,
pubmed-meshheading:1407234-Middle Aged,
pubmed-meshheading:1407234-Nausea,
pubmed-meshheading:1407234-Prospective Studies,
pubmed-meshheading:1407234-Pruritus,
pubmed-meshheading:1407234-Time Factors,
pubmed-meshheading:1407234-Ursodeoxycholic Acid
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pubmed:year |
1992
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pubmed:articleTitle |
Ursodeoxycholic acid treatment in primary biliary cirrhosis with the emphasis on late stage disease.
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pubmed:affiliation |
Department of Hepato-gastroenterology, Free University Hospital Amsterdam, Netherlands.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
|