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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6393
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pubmed:dateCreated |
1992-10-28
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pubmed:abstractText |
The candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alpha-locus in some cases of B-cell chronic lymphocytic leukaemias. The protein Bcl-3 contains seven so-called ankyrin repeats. Similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of Bcl-3 are most closely related to those found in I kappa B proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of NF-kappa B activity. No biological function has yet been described for Bcl-3, but it was noted recently that Bcl-3 interferes with DNA-binding of the p50 subunit of NF-kappa B in vitro. Here we demonstrate that Bcl-3 can aid kappa B site-dependent transcription in vivo by counteracting the inhibitory effects of p50/NF-kappa B homodimers. Bcl-3 may therefore aid activation of select NF-kappa B-regulated genes, including those of the human immunodeficiency virus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
359
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pubmed:geneSymbol |
bcl-3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1406939-Animals,
pubmed-meshheading:1406939-Ankyrins,
pubmed-meshheading:1406939-Cell Line,
pubmed-meshheading:1406939-Cell Nucleus,
pubmed-meshheading:1406939-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:1406939-Gene Expression,
pubmed-meshheading:1406939-Glutathione Transferase,
pubmed-meshheading:1406939-HIV,
pubmed-meshheading:1406939-HIV Long Terminal Repeat,
pubmed-meshheading:1406939-Humans,
pubmed-meshheading:1406939-NF-kappa B,
pubmed-meshheading:1406939-Proto-Oncogene Proteins,
pubmed-meshheading:1406939-Recombinant Fusion Proteins,
pubmed-meshheading:1406939-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1406939-T-Lymphocytes,
pubmed-meshheading:1406939-Transcription, Genetic,
pubmed-meshheading:1406939-Transcription Factors,
pubmed-meshheading:1406939-Transcriptional Activation,
pubmed-meshheading:1406939-Transfection,
pubmed-meshheading:1406939-Tumor Necrosis Factor-alpha
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pubmed:year |
1992
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pubmed:articleTitle |
The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition.
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pubmed:affiliation |
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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