Linked Life Data

14058225

Source:http://linkedlifedata.com/resource/pubmed/id/14058225

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1964-2-1
pubmed:abstractText
Four smallpox vaccines from different production laboratories were compared in primary vaccination of young adults. Morbidity rate, high fever rate and prolonged fever rate, as defined in this report, were used as gauges for pathogenic potency. Special batches were prepared, in addition, from two of these vaccines after three passages on calf skin. Two vaccines, prepared from the Elstree strain-a sheep lymph and its third calf-passage-were found to be of low pathogenicity. Two calf lymphs, prepared from the Copenhagen strain and the Bern strain respectively, caused clearly higher rates of illness and of height and duration of fever. Two calf lymphs from the Ecuador strain took up an intermediate position.Vaccine potency, as assessed on the chorio-allantoic membrane of developing chick embryos, seems to be of no significance for the course of vaccinia disease caused by two pustules. Besides the pathogenicity of the vaccinia strain, ill-defined extraneous factors might be of importance for the degree of illness observed after primary smallpox vaccination.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-9686
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-22
pubmed:dateRevised
2011-9-15
pubmed:meshHeading
pubmed:year
1963
pubmed:articleTitle
A COMPARATIVE STUDY OF CLINICAL REACTION OBSERVED AFTER APPLICATION OF SEVERAL SMALLPOX VACCINES IN PRIMARY VACCINATION OF YOUNG ADULTS.
pubmed:publicationType
Journal Article