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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-11-13
pubmed:abstractText
At the ultrastructural level two main categories of microvascular anomalies can be distinguished in the aged rat brain. These categories comprise [1] membranous inclusions within the basement membrane and [2] microvascular deposits, which include microvascular fibrosis and thickening of the basement membrane (BMT). In this study we examined the percentage of microvessels displaying ageing-related malformations in the frontoparietal motor cortex of rats aged 16, 24, 30 and 32 months. The percentage microvessels with membranous inclusions and microvascular deposits both gradually increased until the age of 30 months, after which no further increase was observed. The percentage fibrotic microvessels, however, increased until the age of 30 months, but was decreased at 32 months. This decrease of fibrotic microvessels at 32 months coincided with a proportional increase of cerebral microvessels provided with a thickened basement membrane. Combined with qualitative observations these data suggest that in a very late stage of the ageing process collagen fibrils in microvascular fibrotic plaques are depolymerized and degradated. By this mechanism it appears that microvascular fibrosis is transformed into basement membrane thickening. Long-term application of the calcium entry blocker nimodipine did not influence the amount of microvessels with membranous inclusions within the basement membrane, but in contrast resulted in a prominent reduction of ageing-related microvascular deposits when administered from 24 to 30 months. The effect of a prolonged nimodipine treatment from 24 to 32 months on the amount of microvascular deposits was still significant, however, much less conspicuous. We now conclude that chronic administration of nimodipine delays the formation of microvascular deposits up to the age of 30 months. Furthermore, the beneficial effect of nimodipine treatment from 24 to 30 months on microvascular integrity is not accompanied by a reduced systolic blood pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-72
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application.
pubmed:affiliation
Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
pubmed:publicationType
Journal Article