rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
20
|
pubmed:dateCreated |
1992-11-13
|
pubmed:abstractText |
Beta-carotene is one of the most commonly used compounds in clinical trials of chemopreventive agents in various neoplastic diseases. Animal studies, including our own, have documented that dietary beta-carotene can reduce plasma alpha-tocopherol (vitamin E) levels, but few published studies have examined the clinical or pharmacokinetic ramifications of long-term, high-dose beta-carotene regimens on other fat-soluble vitamins such as alpha-tocopherol.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0027-8874
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
21
|
pubmed:volume |
84
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1559-65
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:1404449-Administration, Oral,
pubmed-meshheading:1404449-Animals,
pubmed-meshheading:1404449-Carotenoids,
pubmed-meshheading:1404449-Dose-Response Relationship, Drug,
pubmed-meshheading:1404449-Double-Blind Method,
pubmed-meshheading:1404449-Female,
pubmed-meshheading:1404449-Humans,
pubmed-meshheading:1404449-Male,
pubmed-meshheading:1404449-Mice,
pubmed-meshheading:1404449-Mice, Inbred C3H,
pubmed-meshheading:1404449-Middle Aged,
pubmed-meshheading:1404449-Models, Biological,
pubmed-meshheading:1404449-Random Allocation,
pubmed-meshheading:1404449-Reference Values,
pubmed-meshheading:1404449-Regression Analysis,
pubmed-meshheading:1404449-Skin,
pubmed-meshheading:1404449-Time Factors,
pubmed-meshheading:1404449-Vitamin E,
pubmed-meshheading:1404449-beta Carotene
|
pubmed:year |
1992
|
pubmed:articleTitle |
Reduction in plasma or skin alpha-tocopherol concentration with long-term oral administration of beta-carotene in humans and mice.
|
pubmed:affiliation |
Cancer Prevention and Control Program, Arizona Cancer Center, Tucson 85724.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
|