| pubmed-article:1402918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0003577 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0006772 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0001492 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:1402918 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:1402918 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1402918 | pubmed:dateCreated | 1992-11-20 | lld:pubmed |
| pubmed-article:1402918 | pubmed:abstractText | Studies in Aplysia and Drosophila have suggested that Ca2+/calmodulin-sensitive adenylyl cyclase may act as a site of convergence for the cellular representations of the conditioned stimulus (Ca2+ influx) and unconditioned stimulus (facilitatory transmitter) during elementary associative learning. This hypothesis predicts that the rise in intracellular free Ca2+ concentration produced by spike activity during the conditioned stimulus will cause an increase in the activity of adenylyl cyclase. However, published values for the Ca2+ sensitivity of Ca2+/calmodulin-sensitive adenylyl cyclase in mammals and in Drosophila vary widely. The difficulty in evaluating whether adenylyl cyclase would be activated by physiological elevations in intracellular Ca2+ levels is in part a consequence of the use of Ca2+/EGTA buffers, which are prone to several types of errors. Using a procedure that minimizes these errors, we have quantified the Ca2+ sensitivity of adenylyl cyclase in membranes from Aplysia, Drosophila, and rat brain with purified species-specific calmodulins. In all three species, adenylyl cyclase was activated by an increase in free Ca2+ concentration in the range caused by spike activity. Ca2+ sensitivity was dependent on both calmodulin concentration and Mg2+ concentration. Mg2+ raised the threshold for adenylyl cyclase activation by Ca2+ but also acted synergistically with Ca2+ to activate maximally adenylyl cyclase. | lld:pubmed |
| pubmed-article:1402918 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1402918 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402918 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1402918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1402918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1402918 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1402918 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:1402918 | pubmed:author | pubmed-author:KandelE RER | lld:pubmed |
| pubmed-article:1402918 | pubmed:author | pubmed-author:DudaiYY | lld:pubmed |
| pubmed-article:1402918 | pubmed:author | pubmed-author:AbramsT WTW | lld:pubmed |
| pubmed-article:1402918 | pubmed:author | pubmed-author:YovellYY | lld:pubmed |
| pubmed-article:1402918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1402918 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:1402918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1402918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1402918 | pubmed:pagination | 1736-44 | lld:pubmed |
| pubmed-article:1402918 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1402918 | pubmed:meshHeading | pubmed-meshheading:1402918-... | lld:pubmed |
| pubmed-article:1402918 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1402918 | pubmed:articleTitle | A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat. | lld:pubmed |
| pubmed-article:1402918 | pubmed:affiliation | Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York. | lld:pubmed |
| pubmed-article:1402918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1402918 | pubmed:publicationType | Comparative Study | lld:pubmed |
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