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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-11-25
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pubmed:abstractText |
Activin A/erythroid differentiation factor (EDF), a dimeric polypeptide hormone composed of two beta A subunits, regulates growth and erythroid differentiation of human hematopoietic progenitor and erythroleukemia cells. We have identified activated human peripheral blood monocytes as a natural source of activin A/EDF. In these cells, lipopolysaccharide (LPS) induced rapidly the expression of the beta A subunit mRNAs through protein kinase C-dependent transcriptional regulation. The beta A subunit mRNA expression was also increased by 1,25-dihydroxyvitamin D3, an inducer of macrophage maturation of monocytes. Western analysis with an anti-beta A antibody and an erythroid differentiation bioassay confirmed that the conditioned media of LPS-activated monocytes contained the activin A/EDF protein. We suggest that monocyte/macrophage-derived activin A/EDF may not only modulate hematopoiesis but may also act as a mediator molecule in the diverse physiologic and pathogenetic events in which these cells are involved.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-1542647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-164031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-1690989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-1730078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-2113616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-2265241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-2541142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-2610684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-2829170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-3045562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-3194407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-3267209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-3470005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-3696240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-3754442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-6090941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-6238627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1402687-6322116
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1449-52
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1402687-Activins,
pubmed-meshheading:1402687-Base Sequence,
pubmed-meshheading:1402687-Cells, Cultured,
pubmed-meshheading:1402687-Growth Substances,
pubmed-meshheading:1402687-Hematopoiesis,
pubmed-meshheading:1402687-Humans,
pubmed-meshheading:1402687-Inhibins,
pubmed-meshheading:1402687-Molecular Sequence Data,
pubmed-meshheading:1402687-Monocytes,
pubmed-meshheading:1402687-RNA, Messenger
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pubmed:year |
1992
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pubmed:articleTitle |
Activin A/erythroid differentiation factor is induced during human monocyte activation.
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pubmed:affiliation |
Department of Bacteriology and Immunology, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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