| pubmed-article:1402671 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1402671 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1402671 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1402671 | lifeskim:mentions | umls-concept:C0024296 | lld:lifeskim |
| pubmed-article:1402671 | lifeskim:mentions | umls-concept:C0178679 | lld:lifeskim |
| pubmed-article:1402671 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1402671 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:1402671 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1402671 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1402671 | pubmed:dateCreated | 1992-11-25 | lld:pubmed |
| pubmed-article:1402671 | pubmed:abstractText | Tumor necrosis factor alpha (TNF-alpha), a major mediator of inflammation, also possesses a wide pleiotropism of actions, suggesting its involvement in physiological conditions. TNF-alpha mRNA is present in mouse embryonic tissues and also in fetal thymus and spleen. Repeated injections of a monospecific polyclonal rabbit anti-mouse TNF-alpha antibody in mice, starting either during pregnancy or at birth, led to a severe but transient growth retardation, already present at birth, reaching a 35% decrease in body weight at 3 wk, with complete recovery at 8 wk. The insulin growth factor I (IGF-I) blood levels were decreased to about 50%; growth hormone release and other endocrine functions were unaltered. A marked atrophy of the thymus, spleen, and lymph nodes was also observed, with lymphopenia and impaired development of T and B cell peripheral lymphoid structures. The pathways involving TNF-alpha in IGF-I release and early body growth are probably distinct from those by which TNF-alpha participates in early development of lymphoid tissues, where its low physiological release may contribute to enhance lymphoid cell expansion. | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1402671 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1402671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1402671 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1402671 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1402671 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:VassalliPP | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:PiguetP FPF | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:ZapfJJ | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:GaillardR CRC | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:OeiTT | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:GrauG EGE | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:DanevaTT | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:de KossodoSS | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:PointairePP | lld:pubmed |
| pubmed-article:1402671 | pubmed:author | pubmed-author:FossatiLL | lld:pubmed |
| pubmed-article:1402671 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1402671 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1402671 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:1402671 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1402671 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1402671 | pubmed:pagination | 1259-64 | lld:pubmed |
| pubmed-article:1402671 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:meshHeading | pubmed-meshheading:1402671-... | lld:pubmed |
| pubmed-article:1402671 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1402671 | pubmed:articleTitle | Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development. | lld:pubmed |
| pubmed-article:1402671 | pubmed:affiliation | Department of Pathology, University of Geneva, Switzerland. | lld:pubmed |
| pubmed-article:1402671 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1402671 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1402671 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1402671 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1402671 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1402671 | lld:pubmed |
